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GENE - TERM ANNOTATION REPORT

RGD ID: 621351
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col1a2
Name: collagen type I alpha 2 chain
Acc ID: DOID:11476
Term: osteoporosis
Definition: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
Definition Source(s): MESH:D010024, http://en.wikipedia.org/wiki/Osteoporosis, http://orthoinfo.aaos.org/topic.cfm?topic=a00232, http://www.emedicinehealth.com/osteoporosis/article_em.htm, http://www.mayoclinic.com/health/osteoporosis/DS00128, http://www.medicinenet.com/osteoporosis/article.htm, http://www.niams.nih.gov/Health_Info/Bone/default.asp, http://www.nlm.nih.gov/medlineplus/ency/article/000360.htm, http://www.nof.org/
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISORGD:7309847240710OMIM  
 ISORGD:7309848554872ClinVarClinVar Annotator: match by term: OSTEOPOROSIS, INVOLUTIONAL

PMID:16705691, PMID:17078022, PMID:19344236, PMID:22589248, PMID:25326637, PMID:25450603, PMID:25741868, PMID:25944380, PMID:27519266, PMID:28492532, PMID:7695699, PMID:8094076, PMID:8218237, PMID:9016532
 ISORGD:7309848554872ClinVarClinVar Annotator: match by term: OSTEOPOROSIS, INVOLUTIONAL

PMID:16786509, PMID:25741868, PMID:28492532
 ISORGD:7309848554872ClinVarClinVar Annotator: match by term: OSTEOPOROSIS, INVOLUTIONAL

PMID:17078022, PMID:19344236, PMID:25741868, PMID:28492532, PMID:7695699, PMID:8218237, PMID:9016532
 ISORGD:7309848554872ClinVarClinVar Annotator: match by term: OSTEOPOROSIS, INVOLUTIONAL

PMID:17078022, PMID:22589248, PMID:25741868, PMID:28492532, PMID:7860070, PMID:9272740
 ISORGD:7309848554872ClinVarClinVar Annotator: match by term: OSTEOPOROSIS, INVOLUTIONAL

PMID:21520333, PMID:25741868, PMID:25944380, PMID:28492532
 ISORGD:7309848554872ClinVarClinVar Annotator: match by term: OSTEOPOROSIS, INVOLUTIONAL

PMID:25741868, PMID:26604951, PMID:28492532
 ISORGD:7309848554872ClinVarClinVar Annotator: match by term: OSTEOPOROSIS, INVOLUTIONAL

PMID:25741868, PMID:28492532
 ISORGD:7309848554872ClinVarClinVar Annotator: match by term: Postmenopausal osteoporosis

PMID:1463018, PMID:2052622, PMID:8786074
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.