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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621351
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col1a2
Name: collagen type I alpha 2 chain
Acc ID: CHEBI:50594
Term: carbon nanotube
Definition: A molecule consisting of a graphene cylinder or two or more concentric graphene cylinders.
Chemical ID: MESH:D037742
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7309856480464CTDNanotubes, Carbon analog results in decreased expression of COL1A2 mRNA, Nanotubes, Carbon results in decreased expression of COL1A2 mRNA

PMID:25620056
increases expressionISORGD:7309856480464CTDNanotubes, Carbon analog results in increased expression of COL1A2 mRNA, Nanotubes, Carbon results in increased expression of COL1A2 mRNA, Nanotubes, Carbon results in increased expression of COL1A2 protein

PMID:25510677, PMID:25554681
multiple interactionsISORGD:7309856480464CTD[PTGS2 gene mutant form results in increased susceptibility to [Nanotubes, Carbon co-treated with OVAL protein]] which results in increased expression of COL1A2 mRNA

PMID:23642096
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.