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RGD ID: 621351
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col1a2
Name: collagen type I alpha 2 chain
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:7309856480464CTDAcetaminophen affects the expression of COL1A2 mRNA

decreases expressionISORGD:7309846480464CTDAcetaminophen results in decreased expression of COL1A2 mRNA

increases expressionISORGD:7309856480464CTDAcetaminophen results in increased expression of COL1A2 mRNA

multiple interactionsISORGD:7309856480464CTD[EGR1 protein affects the susceptibility to Acetaminophen] which affects the expression of COL1A2 mRNA, andrographolide inhibits the reaction [Acetaminophen results in increased expression of COL1A2 mRNA], NFE2L2 gene mutant form promotes the reaction [Acetaminophen results in increased expression of COL1A2 mRNA]

PMID:28286204, PMID:29355602
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.