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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621351
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col1a2
Name: collagen type I alpha 2 chain
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDresveratrol results in decreased expression of COL1A2 mRNA

PMID:19228061
affects secretionISORGD:7309846480464CTDresveratrol affects the secretion of COL1A2 protein

PMID:24802182
decreases expressionISORGD:7309856480464CTDresveratrol results in decreased expression of COL1A2 mRNA

PMID:24782617
multiple interactionsISORGD:7309846480464CTDNiacinamide inhibits the reaction [resveratrol inhibits the reaction [TGFB2 protein results in increased expression of COL1A2 mRNA]], resveratrol inhibits the reaction [TGFB2 protein promotes the reaction [EP300 protein binds to COL1A2 promoter]], resveratrol inhibits the reaction [TGFB2 protein results in increased expression of COL1A2 mRNA]

PMID:25707573
multiple interactionsISORGD:7309856480464CTDresveratrol inhibits the reaction [DMD gene mutant form results in increased expression of COL1A2 mRNA], resveratrol inhibits the reaction [IGF1 protein results in increased expression of COL1A2 mRNA]

PMID:23297412, PMID:24782617
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.