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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621351
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col1a2
Name: collagen type I alpha 2 chain
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of COL1A2 mRNA, Carbon Tetrachloride results in increased expression of COL1A2 protein

PMID:10535884, PMID:17056239, PMID:17631135, PMID:18481824, PMID:8878782
multiple interactionsEXP 6480464CTD[Carbon Tetrachloride co-treated with Folic Acid] results in increased expression of COL1A2 mRNA, [Imatinib Mesylate co-treated with Perindopril] inhibits the reaction [Carbon Tetrachloride affects the expression of COL1A2 mRNA], Imatinib Mesylate inhibits the reaction [Carbon Tetrachloride affects the expression of COL1A2 mRNA], Perindopril inhibits the reaction [Carbon Tetrachloride affects the expression of COL1A2 mRNA], PLAU protein inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA], S-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA], Sirolimus inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]

PMID:10535884, PMID:16596278, PMID:18156304, PMID:18481824, PMID:8878782
increases expressionISORGD:7309856480464CTDCarbon Tetrachloride results in increased expression of COL1A2 mRNA

PMID:14512876, PMID:15056808, PMID:15983038, PMID:16012952, PMID:17011172, PMID:17105591, PMID:17484886, PMID:18395096, PMID:25827057, PMID:26853152, PMID:27042213, PMID:27339419, PMID:29987408, PMID:30538632
multiple interactionsISORGD:7309856480464CTD1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA], [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of COL1A2 mRNA, [Chlordecone co-treated with Carbon Tetrachloride] results in increased expression of COL1A2 mRNA, CYBB gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA], HAS3 protein affects the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA], HGF protein inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA], IFNA1 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA], S-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA], STF 083010 inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA], Tretinoin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA], YBX1 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]

PMID:14512876, PMID:15983038, PMID:16012952, PMID:17011172, PMID:17105591, PMID:18395096, PMID:25827057, PMID:26853152, PMID:27042213, PMID:30517762, PMID:30538632
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.