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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621351
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col1a2
Name: collagen type I alpha 2 chain
Acc ID: CHEBI:15414
Term: S-adenosyl-L-methionine
Definition: A sulfonium compound that is the S-adenosyl derivative of L-methionine. It is an intermediate in the metabolic pathway of methionine.
Chemical ID: MESH:D012436
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDS-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]

PMID:8878782
decreases expressionISORGD:7309846480464CTDS-Adenosylmethionine results in decreased expression of COL1A2 mRNA

PMID:15983038
multiple interactionsISORGD:7309856480464CTDS-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA], S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter], S-Adenosylmethionine inhibits the reaction [TGFB1 protein binds to COL1A2 promoter]

PMID:15983038
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.