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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621351
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col1a2
Name: collagen type I alpha 2 chain
Acc ID: CHEBI:15343
Term: acetaldehyde
Definition: The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
Chemical ID: MESH:D000079
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7309846480464CTDAcetaldehyde results in increased expression of COL1A2 mRNA

PMID:11343241, PMID:16025520
increases expressionISORGD:7309856480464CTDAcetaldehyde results in increased expression of COL1A2 mRNA

PMID:10069557, PMID:10729205, PMID:15130784, PMID:7768510, PMID:8294106, PMID:8660697, PMID:9143363
multiple interactionsISORGD:7309846480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA], 4-hydroxymercuribenzoate inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA], calphostin C inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA], Sirolimus inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA], SMAD3 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA], SMAD4 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA], SP1 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA], wortmannin inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA]

PMID:11343241, PMID:16025520
multiple interactionsISORGD:7309856480464CTDAcetaldehyde promotes the reaction [NFIC protein binds to COL1A2 promoter], calphostin C inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA], LEP protein affects the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA], NFIC protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA], Tretinoin inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA], tricyclodecane-9-yl-xanthogenate inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA]

PMID:10069557, PMID:10729205, PMID:15130784, PMID:7768510
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.