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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: As3mt
Name: arsenite methyltransferase
Acc ID: CHEBI:48765
Term: dimethylarsinic acid
Definition: The organoarsenic compound that is arsenic acid substituted on the central arsenic atom with two methyl groups.
Chemical ID: MESH:D002101
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13506976480464CTD[AS3MT gene polymorphism affects the susceptibility to Arsenic] which results in increased abundance of Cacodylic Acid, [AS3MT protein polymorphism results in increased metabolism of arsenite] which results in increased chemical synthesis of Cacodylic Acid, [AS3MT protein polymorphism results in increased metabolism of monomethylarsonic acid] which results in increased chemical synthesis of Cacodylic Acid, [AS3MT protein results in increased metabolism of arsenite] which results in increased chemical synthesis of Cacodylic Acid, [AS3MT protein results in increased metabolism of monomethylarsonic acid] which results in increased chemical synthesis of Cacodylic Acid

PMID:22868225, PMID:24845704
multiple interactionsISORGD:7332926480464CTDAS3MT protein affects the reaction [APOE protein affects the susceptibility to Cacodylic Acid]

PMID:28728140
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.