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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: As3mt
Name: arsenite methyltransferase
Acc ID: CHEBI:47217
Term: arsane
Definition: An arsine that has formula 77.94542.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects methylationEXP 6480464CTDAS3MT protein affects the methylation of Arsenic

PMID:20949432
increases methylationEXP 6480464CTDAS3MT protein results in increased methylation of Arsenic

PMID:15025511, PMID:15808521, PMID:16102566
multiple interactionsEXP 6480464CTDAurothioglucose inhibits the reaction [AS3MT protein results in increased methylation of Arsenic], Dithiothreitol promotes the reaction [AS3MT protein results in increased methylation of Arsenic], tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein results in increased methylation of Arsenic]

PMID:15025511
affects abundanceISORGD:13506976480464CTDAS3MT gene polymorphism affects the abundance of Arsenic metabolite

PMID:24239724
affects metabolic processingISORGD:13506976480464CTDAS3MT gene polymorphism affects the metabolism of Arsenic, AS3MT gene SNP affects the metabolism of Arsenic, AS3MT intron polymorphism affects the metabolism of Arsenic, AS3MT polymorphism affects the metabolism of Arsenic, AS3MT protein affects the metabolism of Arsenic, AS3MT protein polymorphism affects the metabolism of Arsenic, AS3MT SNP affects the metabolism of Arsenic

PMID:15929903, PMID:16407288, PMID:17450230, PMID:17637926, PMID:18682255, PMID:18976679, PMID:20532380, PMID:21247820, PMID:23341986, PMID:23665909, PMID:25156000, PMID:27327299, PMID:27352405, PMID:27637898
affects methylationISORGD:13506976480464CTDAS3MT gene polymorphism affects the methylation of Arsenic, AS3MT gene SNP affects the methylation of Arsenic

PMID:19371612, PMID:29859237, PMID:30153448
affects response to substanceISORGD:13506976480464CTDAS3MT gene polymorphism affects the susceptibility to Arsenic, AS3MT gene SNP affects the susceptibility to Arsenic, AS3MT protein polymorphism affects the susceptibility to Arsenic, AS3MT SNP affects the susceptibility to Arsenic

PMID:19538983, PMID:20547570, PMID:24845704, PMID:25156000, PMID:26366667, PMID:28537708
affects response to substanceISORGD:7332926480464CTDAS3MT protein affects the susceptibility to Arsenic

PMID:21385732
decreases response to substanceISORGD:13506976480464CTDAS3MT gene SNP results in decreased susceptibility to Arsenic

PMID:23070617
increases abundanceISORGD:13506976480464CTDAS3MT protein results in increased abundance of Arsenic metabolite

PMID:21537954
increases exportISORGD:7332926480464CTDAS3MT protein results in increased export of Arsenic

PMID:20887743
increases metabolic processingISORGD:13506976480464CTDAS3MT protein results in increased metabolism of Arsenic

PMID:18414634
increases methylationISORGD:13506976480464CTDAS3MT gene polymorphism results in increased methylation of Arsenic, AS3MT protein results in increased methylation of Arsenic

PMID:15808521, PMID:16841956, PMID:18334919, PMID:19167370, PMID:20049124, PMID:22005461
increases methylationISORGD:7332926480464CTDAS3MT protein results in increased methylation of Arsenic

PMID:15808521
increases response to substanceISORGD:13506976480464CTDAS3MT gene SNP results in increased susceptibility to Arsenic

PMID:22747749
multiple interactionsISORGD:13506976480464CTD[AS3MT gene polymorphism affects the susceptibility to Arsenic] which results in increased abundance of Cacodylic Acid, [AS3MT gene polymorphism affects the susceptibility to Arsenic] which results in increased abundance of monomethylarsonic acid, [AS3MT gene SNP affects the susceptibility to Arsenic] which affects the abundance of dimethylarsinous acid, [AS3MT gene SNP affects the susceptibility to Arsenic] which affects the abundance of monomethylarsonous acid, AS3MT gene polymorphism affects the reaction [PNP gene polymorphism affects the susceptibility to Arsenic], AS3MT gene SNP affects the methylation of and affects the susceptibility to Arsenic, Folic Acid promotes the reaction [Vitamin B 12 promotes the reaction [AS3MT protein results in increased methylation of Arsenic]], Selenium inhibits the reaction [AS3MT protein results in increased methylation of Arsenic], Vitamin B 12 promotes the reaction [AS3MT protein results in increased methylation of Arsenic]

PMID:19167370, PMID:20049124, PMID:21605854, PMID:24845704, PMID:28235556, PMID:29859237
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.