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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: As3mt
Name: arsenite methyltransferase
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases response to substanceISORGD:7332926480464CTDAS3MT results in decreased susceptibility to arsenite

PMID:20423714
increases chemical synthesisISORGD:13506976480464CTDAS3MT protein results in increased chemical synthesis of arsenite analog

PMID:28537708
increases metabolic processingISORGD:13506976480464CTDAS3MT protein polymorphism results in increased metabolism of arsenite, AS3MT protein results in increased metabolism of arsenite

PMID:22868225
increases methylationISORGD:13506976480464CTDAS3MT protein results in increased methylation of arsenite

PMID:25325836
multiple interactionsISORGD:13506976480464CTD[AS3MT protein binds to and results in increased methylation of arsenite] which results in increased chemical synthesis of dimethylarsinous acid, [AS3MT protein polymorphism results in increased metabolism of arsenite] which results in increased chemical synthesis of Cacodylic Acid, [AS3MT protein polymorphism results in increased metabolism of arsenite] which results in increased chemical synthesis of dimethylarsinous acid, [AS3MT protein polymorphism results in increased metabolism of arsenite] which results in increased chemical synthesis of monomethylarsonic acid, [AS3MT protein results in increased metabolism of arsenite] which results in increased chemical synthesis of Cacodylic Acid, [AS3MT protein results in increased metabolism of arsenite] which results in increased chemical synthesis of dimethylarsinous acid, [AS3MT protein results in increased metabolism of arsenite] which results in increased chemical synthesis of monomethylarsonic acid, AS3MT protein binds to and results in increased methylation of arsenite, Cysteine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite], Cysteine promotes the reaction [AS3MT protein results in increased methylation of arsenite], Dithiothreitol promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite], Glutathione promotes the reaction [[AS3MT protein polymorphism results in increased metabolism of arsenite] which results in increased chemical synthesis of dimethylarsinous acid], Glutathione promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite], Glutathione promotes the reaction [AS3MT protein results in increased methylation of arsenite], S-Adenosylmethionine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite], tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite], tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein results in increased methylation of arsenite]

PMID:22868225, PMID:22955273, PMID:25349987
multiple interactionsISORGD:7332926480464CTDAS3MT protein affects the methylation of and affects the susceptibility to arsenite

PMID:21934131
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.