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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: As3mt
Name: arsenite methyltransferase
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
As3mtincreases expressionEXP 6480464CTDsodium arsenite results in increased expression of AS3MT mRNAPMID:35227329
As3mtaffects metabolic processingISOAS3MT (Homo sapiens)6480464CTDAS3MT protein affects the metabolism of sodium arsenitePMID:16407288
As3mtdecreases expressionISOAS3MT (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of AS3MT mRNAPMID:37956786
As3mtdecreases metabolic processingISOAS3MT (Homo sapiens)6480464CTDAS3MT protein polymorphism results in decreased metabolism of sodium arsenitePMID:16407288
As3mtincreases expressionISOAS3MT (Homo sapiens)6480464CTDsodium arsenite results in increased expression of AS3MT mRNA; sodium arsenite results in increased expression of AS3MT proteinPMID:25194983 PMID:36399430
As3mtincreases expressionISOAs3mt (Mus musculus)6480464CTDsodium arsenite results in increased expression of AS3MT mRNAPMID:33141059
As3mtincreases metabolic processingISOAS3MT (Homo sapiens)6480464CTDAS3MT protein polymorphism results in increased metabolism of sodium arsenitePMID:16407288
As3mtincreases methylationISOAS3MT (Homo sapiens)6480464CTDAS3MT protein results in increased methylation of sodium arsenitePMID:21447609
As3mtincreases response to substanceISOAS3MT (Homo sapiens)6480464CTDAS3MT protein results in increased susceptibility to sodium arsenitePMID:21537954
As3mtmultiple interactionsISOAS3MT (Homo sapiens)6480464CTD[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of AS3MT mRNA; AS3MT protein promotes the reaction [sodium arsenite results in decreased expression of CCN1 protein]; AS3MT protein promotes the reaction [sodium arsenite results in decreased expression of CDH2 protein]; AS3MT protein promotes the reaction [sodium arsenite results in decreased expression of MMP2 protein]; AS3MT protein promotes the reaction [sodium arsenite results in decreased expression of VIM protein]; AS3MT protein promotes the reaction [sodium arsenite results in decreased stability of CCN1 mRNA]; Unithiol inhibits the reaction [sodium arsenite results in increased expression of AS3MT mRNA]; Unithiol inhibits the reaction [sodium arsenite results in increased expression of AS3MT protein]PMID:25194983 PMID:32930475 PMID:37682722
As3mtmultiple interactionsISOAs3mt (Mus musculus)6480464CTDAS3MT protein affects the reaction [[APOE protein affects the susceptibility to sodium arsenite] which results in decreased expression of ACTA2 protein]; AS3MT protein affects the reaction [APOE protein affects the susceptibility to sodium arsenite]PMID:28728140
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