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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: As3mt
Name: arsenite methyltransferase
Acc ID: CHEBI:22633
Term: arsenite ion
Definition: An arsenic oxoanion resulting from the removal of one or more protons from arsenous acid.
Chemical ID: MESH:D018053
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases response to substanceEXP 6480464CTDAS3MT protein results in increased susceptibility to Arsenites

PMID:19411561
multiple interactionsEXP 6480464CTD[AS3MT protein results in increased susceptibility to Arsenites] which affects the expression of CDC45 mRNA, [AS3MT protein results in increased susceptibility to Arsenites] which affects the expression of CHAF1A mRNA, [AS3MT protein results in increased susceptibility to Arsenites] which affects the expression of MCM2 mRNA, [AS3MT protein results in increased susceptibility to Arsenites] which affects the expression of PCNA mRNA, [AS3MT protein results in increased susceptibility to Arsenites] which affects the expression of POLA2 mRNA

PMID:19411561
multiple interactionsISORGD:13506976480464CTDAS3MT protein results in increased methylation of and results in increased susceptibility to Arsenites

PMID:26577531
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.