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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: As3mt
Name: arsenite methyltransferase
Acc ID: CHEBI:17561
Term: L-cysteine
Definition: An optically active form of cysteine having L-configuration.
Chemical ID: MESH:D003545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects foldingISORGD:13506976480464CTDCysteine affects the folding of AS3MT protein

PMID:22955273
increases reductionISORGD:13506976480464CTDCysteine results in increased reduction of AS3MT protein

PMID:25349987
multiple interactionsISORGD:13506976480464CTDCysteine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite], Cysteine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine], Cysteine promotes the reaction [AS3MT protein results in increased chemical synthesis of dimethylarsinous acid], Cysteine promotes the reaction [AS3MT protein results in increased chemical synthesis of methylarsonite], Cysteine promotes the reaction [AS3MT protein results in increased methylation of arsenite]

PMID:22955273, PMID:25349987
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.