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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:8772
Term: raloxifene
Definition: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.
Chemical ID: MESH:D020849
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9multiple interactionsEXP 6480464CTD[9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride co-treated with Fluoxetine] affects the expression of MMP9 protein; [9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride] affects the expression of MMP9 proteinPMID:31332895
Mmp9decreases activityISOMMP9 (Homo sapiens)6480464CTDRaloxifene Hydrochloride results in decreased activity of MMP9 proteinPMID:17582780
Mmp9decreases expressionISOMMP9 (Homo sapiens)6480464CTDRaloxifene Hydrochloride results in decreased expression of MMP9 mRNAPMID:17582780
Mmp9increases expressionISOMmp9 (Mus musculus)6480464CTDRaloxifene Hydrochloride results in increased expression of MMP9 mRNAPMID:22841776
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