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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9increases activityEXP 6480464CTDperfluorooctane sulfonic acid results in increased activity of MMP9 proteinPMID:28973641
Mmp9decreases expressionISOMMP9 (Homo sapiens)6480464CTDperfluorooctane sulfonic acid results in decreased expression of MMP9 mRNAPMID:32219433 PMID:32790152
Mmp9increases expressionISOMmp9 (Mus musculus)6480464CTDperfluorooctane sulfonic acid results in increased expression of MMP9 proteinPMID:27818224
Mmp9multiple interactionsISOMmp9 (Mus musculus)6480464CTDATF2 protein promotes the reaction [perfluorooctane sulfonic acid results in increased expression of MMP9 protein]; SB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of MMP9 protein]PMID:27818224
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