GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mmp9 | decreases activity | ISO | MMP9 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased activity of MMP9 protein | PMID:21969006 PMID:23851143 PMID:24680928 PMID:27039805 | Mmp9 | decreases expression | ISO | MMP9 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of MMP9 mRNA; Arsenic Trioxide results in decreased expression of MMP9 protein | PMID:15962302 PMID:16624393 PMID:19128835 PMID:19236750 PMID:19350554 PMID:19804631 PMID:20471514 PMID:20592496 PMID:21969006 PMID:23253724 PMID:23851143 PMID:24680928 PMID:26238599 PMID:26705709 PMID:27039805 | Mmp9 | decreases expression | ISO | Mmp9 (Mus musculus) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of MMP9 mRNA; Arsenic Trioxide results in decreased expression of MMP9 protein | PMID:23210436 | Mmp9 | decreases response to substance | ISO | MMP9 (Homo sapiens) | 6480464 | CTD | MMP9 protein results in decreased susceptibility to Arsenic Trioxide | PMID:24956101 | Mmp9 | increases expression | ISO | MMP9 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased expression of MMP9; Arsenic Trioxide results in increased expression of MMP9 mRNA; Arsenic Trioxide results in increased expression of MMP9 protein | PMID:15949266 PMID:24956101 PMID:25728215 PMID:27829220 | Mmp9 | multiple interactions | ISO | MMP9 (Homo sapiens) | 6480464 | CTD | [acetyl-11-ketoboswellic acid co-treated with Arsenic Trioxide] results in decreased activity of MMP9 protein; [acetyl-11-ketoboswellic acid co-treated with Arsenic Trioxide] results in decreased expression of MMP9 mRNA; [acetyl-11-ketoboswellic acid co-treated with Arsenic Trioxide] results in decreased secretion of MMP9 protein; [Arsenic Trioxide co-treated with Silybin] results in decreased expression of MMP9 mRNA; [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of MMP9 mRNA; [Silybin co-treated with Arsenic Trioxide] results in decreased activity of MMP9 protein; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of MMP9 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased secretion of MMP9 protein]; Arsenic Trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; Arsenic Trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of and results in increased activity of MMP9 protein]; Arsenic Trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]; Arsenic Trioxide results in decreased expression of and results in decreased secretion of MMP9 protein; Arsenic Trioxide results in increased expression of and affects the localization of and results in decreased secretion of MMP9 protein; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [Arsenic Trioxide results in increased expression of and affects the localization of MMP9 protein]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [Arsenic Trioxide results in increased expression of MMP9 mRNA]; Dactinomycin inhibits the reaction [Arsenic Trioxide results in increased expression of MMP9 mRNA]; GH1 protein promotes the reaction [Arsenic Trioxide results in decreased activity of MMP9 protein]; GH1 protein promotes the reaction [Arsenic Trioxide results in decreased expression of MMP9 mRNA]; HMOX1 protein inhibits the reaction [Arsenic Trioxide results in increased expression of MMP9 mRNA]; HMOX1 protein inhibits the reaction [Arsenic Trioxide results in increased expression of MMP9 protein]; JUN protein promotes the reaction [Arsenic Trioxide results in increased expression of MMP9 mRNA]; JUN protein promotes the reaction [Arsenic Trioxide results in increased expression of MMP9 protein]; MIR491 mRNA affects the reaction [Arsenic Trioxide results in decreased expression of MMP9 mRNA]; MMP9 protein inhibits the reaction [Arsenic Trioxide inhibits the reaction [BCL2L11 protein binds to MCL1 protein]]; MMP9 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2L1 protein]; MMP9 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of MCL1 protein]; MMP9 protein inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; MMP9 protein inhibits the reaction [Arsenic Trioxide results in increased expression of BCL2L11 protein]; SB 203580 inhibits the reaction [Arsenic Trioxide results in increased expression of MMP9 mRNA]; SB 203580 inhibits the reaction [Arsenic Trioxide results in increased expression of MMP9 protein]; SR 11302 inhibits the reaction [Arsenic Trioxide results in increased expression of MMP9 mRNA]; SR 11302 inhibits the reaction [Arsenic Trioxide results in increased expression of MMP9 protein]; zinc protoporphyrin promotes the reaction [Arsenic Trioxide results in increased expression of MMP9 protein] | PMID:15962302 PMID:19350554 PMID:21078271 PMID:21969006 PMID:23253724 PMID:23851143 PMID:24680928 PMID:24956101 PMID:27829220 PMID:29274334 | | ||||||||||||||||||||||
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