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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:28304
Term: heparin
Definition: A highly sulfated linear glycosaminoglycan comprising complex patterns of uronic acid-(1->4)-D-glucosamine repeating subunits. Used as an injectable anticoagulant, it has the highest negative charge density of any known biological molecule.
Chemical ID: MESH:D006493
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9decreases activityISOMMP9 (Homo sapiens)6480464CTDHeparin results in decreased activity of MMP9 proteinPMID:10958381
Mmp9increases expressionISOMmp9 (Mus musculus)6480464CTDHeparin results in increased expression of MMP9 mRNA; Heparin results in increased expression of MMP9 proteinPMID:14630814 PMID:16190367
Mmp9multiple interactionsISOMmp9 (Mus musculus)6480464CTDHeparin results in increased metabolism of and results in increased activity of MMP9 proteinPMID:14630814
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