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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:25434
Term: bis(2-chloroethyl) sulfide
Definition: An ethyl sulfide that is diethyl sulfide in which a hydrogen from each of the terminal methyl groups is replaced by a chlorine. It is a powerful vesicant regulated under the Chemical Weapons Convention.
Chemical ID: MESH:D009151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9increases expressionEXP 6480464CTDMustard Gas results in increased expression of MMP9 proteinPMID:20659490 PMID:33002157 PMID:34390737
Mmp9increases expressionISOMMP9 (Homo sapiens)6480464CTDMustard Gas results in increased expression of MMP9 mRNAPMID:18809459
Mmp9increases expressionISOMmp9 (Mus musculus)6480464CTDMustard Gas results in increased expression of MMP9 mRNA; Mustard Gas results in increased expression of MMP9 proteinPMID:16489579 PMID:18955075 PMID:21939433 PMID:25275893 PMID:32479919
Mmp9increases secretionISOMMP9 (Homo sapiens)6480464CTDMustard Gas results in increased secretion of MMP9 proteinPMID:18809459
Mmp9multiple interactionsISOMMP9 (Homo sapiens)6480464CTDMustard Gas inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 mRNA]; Mustard Gas inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 protein]PMID:26082309
Mmp9multiple interactionsISOMmp9 (Mus musculus)6480464CTDMatrix Metalloproteinase Inhibitors inhibits the reaction [Mustard Gas results in increased expression of MMP9 mRNA]; Matrix Metalloproteinase Inhibitors inhibits the reaction [Mustard Gas results in increased expression of MMP9 protein]PMID:32479919
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