GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mmp2 | decreases activity | ISO | MMP2 (Homo sapiens) | 6480464 | CTD | (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone results in decreased activity of MMP2 protein | PMID:30776504 | Mmp2 | decreases expression | ISO | MMP2 (Homo sapiens) | 6480464 | CTD | (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone results in decreased expression of MMP2 protein | PMID:29883990 PMID:31991773 | Mmp2 | multiple interactions | ISO | MMP2 (Homo sapiens) | 6480464 | CTD | JTE 907 inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone analog results in decreased expression of MMP2 protein] | PMID:31991773 | |
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