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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:6801
Term: metformin
Definition: A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Chemical ID: MESH:D008687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2decreases activityISOMMP2 (Homo sapiens)6480464CTDMetformin results in decreased activity of MMP2 proteinPMID:20590612
Mmp2decreases expressionISOMMP2 (Homo sapiens)6480464CTDMetformin results in decreased expression of MMP2 mRNAPMID:22246099
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTD[Metformin co-treated with NVP-BKM120] results in decreased expression of MMP2 protein; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein]PMID:20590612 PMID:38479708
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