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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:3638
Term: chloroquine
Definition: An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Chemical ID: MESH:D002738
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2decreases expressionISOMMP2 (Homo sapiens)6480464CTDChloroquine results in decreased expression of MMP2 mRNA; Chloroquine results in decreased expression of MMP2 proteinPMID:24273604 PMID:34278709
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTDChloroquine inhibits the reaction [cordycepin results in decreased activity of MMP2 protein]; Chloroquine inhibits the reaction [cordycepin results in decreased expression of MMP2 mRNA]; Sirolimus inhibits the reaction [Chloroquine results in decreased expression of MMP2 protein]PMID:34278709 PMID:36299321
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