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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:35807
Term: N-nitrosodimethylamine
Definition: A nitrosamine that has formula C2H6N2O.
Chemical ID: MESH:D004128
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2decreases activityEXP 6480464CTDDimethylnitrosamine results in decreased activity of MMP2 proteinPMID:17348192
Mmp2decreases expressionEXP 6480464CTDDimethylnitrosamine results in decreased expression of MMP2 proteinPMID:16965748
Mmp2increases activityEXP 6480464CTDDimethylnitrosamine results in increased activity of MMP2 proteinPMID:15161499
Mmp2increases expressionEXP 6480464CTDDimethylnitrosamine results in increased expression of MMP2 mRNAPMID:15571005 PMID:16042886 PMID:16169303 PMID:17036385 PMID:25380136
Mmp2multiple interactionsEXP 6480464CTD[Silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP2 mRNA]; Drugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in decreased expression of MMP2 protein]; Drugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP2 mRNA]; pirfenidone inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP2 mRNA]; Plant Preparations inhibits the reaction [Dimethylnitrosamine results in decreased activity of MMP2 protein]PMID:15571005 PMID:16169303 PMID:16965748 PMID:17036385 PMID:17348192
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