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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTD[AG 1879 co-treated with Fulvestrant] inhibits the reaction [Chlorpyrifos results in increased expression of MMP2 protein]; [bisphenol A co-treated with Fulvestrant] results in decreased methylation of MMP2 gene; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of MMP2 mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of MMP2 protein]; Fulvestrant inhibits the reaction [Chlorpyrifos results in increased expression of MMP2 protein]; Fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP2 mRNA]; Fulvestrant inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP2 protein]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of MMP2 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of MMP2 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of MMP2 protein]; Fulvestrant inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of MMP2 mRNA]; Fulvestrant inhibits the reaction [nonylphenol results in increased expression of MMP2 protein]; Fulvestrant inhibits the reaction [Triclosan results in increased expression of MMP2 protein]PMID:19956873 PMID:26407941 PMID:28390675 PMID:28844962 PMID:31601247 PMID:32956863
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