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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2multiple interactionsEXP 6480464CTDGenistein inhibits the reaction [Ethanol results in decreased expression of MMP2 mRNA]PMID:23274713
Mmp2decreases activityISOMMP2 (Homo sapiens)6480464CTDGenistein results in decreased activity of MMP2 proteinPMID:16598420
Mmp2decreases expressionISOMMP2 (Homo sapiens)6480464CTDGenistein results in decreased expression of MMP2 mRNAPMID:15754008
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTDGenistein inhibits the reaction [bisphenol A results in increased expression of MMP2 protein]; Genistein inhibits the reaction [Estradiol results in increased expression of MMP2 protein]; Genistein inhibits the reaction [nonylphenol results in increased expression of MMP2 protein]PMID:26407941
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