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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:16118
Term: berberine
Definition: A botanical anti-fungal agent that has formula C20H18NO4.
Chemical ID: MESH:D001599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2decreases activityEXP 6480464CTDBerberine results in decreased activity of MMP2 proteinPMID:18294404
Mmp2decreases expressionEXP 6480464CTDBerberine results in decreased expression of MMP2 proteinPMID:18294404
Mmp2multiple interactionsEXP 6480464CTDarsenic trioxide promotes the reaction [Berberine results in decreased activity of MMP2 protein]; arsenic trioxide promotes the reaction [Berberine results in decreased expression of MMP2 protein]; Berberine promotes the reaction [arsenic trioxide results in decreased activity of MMP2 protein]PMID:18294404
Mmp2decreases activityISOMMP2 (Homo sapiens)6480464CTDBerberine results in decreased activity of MMP2 proteinPMID:18294404 PMID:33325633
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP2 protein]]; Arsenic Trioxide promotes the reaction [Berberine results in decreased activity of MMP2 protein]; Berberine promotes the reaction [Arsenic Trioxide results in decreased activity of MMP2 protein]; EGF protein inhibits the reaction [Berberine results in decreased activity of MMP2 protein]PMID:18294404 PMID:33325633
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