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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621315
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map1lc3b
Name: microtubule-associated protein 1 light chain 3 beta
Acc ID: CHEBI:37415
Term: alpha-amanitin
Definition: A heterodetic cyclic peptide consisting of eight amino acid residues and containing a thioether bridge between a cysteine and a tryptophan residue. It is found in a number of poisonous mushrooms, including Amanita phalloides (the death cap), Galerina marginata, and and Conocybe filaris.
Chemical ID: MESH:D053959
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map1lc3bmultiple interactionsEXP 6480464CTDAlpha-Amanitin results in increased expression of and results in increased lipidation of MAP1LC3B proteinPMID:37329965
Map1lc3baffects lipidationISOMAP1LC3B (Homo sapiens)6480464CTDAlpha-Amanitin affects the lipidation of MAP1LC3B proteinPMID:37329965
Map1lc3bmultiple interactionsISOMAP1LC3B (Homo sapiens)6480464CTD3-methyladenine affects the reaction [Alpha-Amanitin affects the lipidation of MAP1LC3B protein]; Alpha-Amanitin inhibits the reaction [dorsomorphin results in decreased lipidation of MAP1LC3B protein]PMID:37329965
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