Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621295
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mvk
Name: mevalonate kinase
Acc ID: CHEBI:28600
Term: farnesol
Definition: A farnesane sesquiterpenoid that is dodeca-2,6,10-triene substituted by methyl groups at positions 3, 7 and 11 and a hydroxy group at position 1.
Chemical ID: MESH:D005204
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:7320316480464CTDFarnesol results in decreased activity of MVK protein

PMID:9392419
multiple interactionsISORGD:7320316480464CTDFarnesol inhibits the reaction [[MVK gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL1B protein], Farnesol inhibits the reaction [MVK gene mutant form results in increased susceptibility to Lipopolysaccharides], Farnesol inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate], Farnesol inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]

PMID:20304105, PMID:9392419
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.