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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621295
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mvk
Name: mevalonate kinase
Acc ID: CHEBI:24229
Term: geranylgeraniol
Definition: A diterpenoid that is hexadeca-2,6,10,14-tetraene substituted by methyl groups at positions 3, 7, 11 and 15 and a hydroxy group at position 1.
Chemical ID: MESH:C017338
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7320316480464CTD[MVK gene mutant form results in increased activity of HMGCR protein] which results in increased susceptibility to geranylgeraniol, geranylgeraniol inhibits the reaction [[MVK gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL1B protein], geranylgeraniol inhibits the reaction [MVK gene mutant form results in increased susceptibility to Lipopolysaccharides], MVK gene mutant form promotes the reaction [geranylgeraniol results in decreased activity of HMGCR protein]

PMID:12477733, PMID:20304105
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.