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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621282
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Birc3
Name: baculoviral IAP repeat-containing 3
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Birc3decreases expressionISOBIRC3 (Homo sapiens)6480464CTDCurcumin results in decreased expression of BIRC3 mRNA; Curcumin results in decreased expression of BIRC3 proteinPMID:17596214 PMID:19372569 PMID:27430728
Birc3increases expressionISOBIRC3 (Homo sapiens)6480464CTDCurcumin results in increased expression of BIRC3 mRNAPMID:15911101 PMID:16101141
Birc3multiple interactionsISOBIRC3 (Homo sapiens)6480464CTD[arsenic trioxide co-treated with Curcumin] results in decreased expression of BIRC3 protein; [Curcumin co-treated with Doxorubicin] affects the expression of BIRC3 mRNA; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BIRC3 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]PMID:15911101 PMID:16219905 PMID:16243823 PMID:27430728
Birc3multiple interactionsISOBirc3 (Mus musculus)6480464CTD[Curcumin co-treated with Gemcitabine] results in decreased expression of BIRC3 proteinPMID:17440100
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