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GENE - TERM ANNOTATION REPORT

RGD ID: 621246
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Top1
Name: DNA topoisomerase I
Acc ID: GO:0003917
Term: DNA topoisomerase type I (single strand cut, ATP-independent) activity
Definition: Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
Definition Source(s): PMID:8811192
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Top1 IDA 1580856RGD  
Top1enablesISOTOP1 (Homo sapiens)1624291RGD PMID:14594810 PMID:14654701 PMID:17355975 PMID:8567649 PMID:8631793 PMID:8631794 PMID:9611241

PMID:14594810 PMID:14654701 PMID:17355975 PMID:8567649 PMID:8631793 PMID:8631794 PMID:9611241
Top1enablesISOTop1 (Mus musculus)1624291RGD PMID:16261531 PMID:7842491 PMID:9094096

PMID:16261531 PMID:7842491 PMID:9094096
Top1enablesIBACGD:CAL0000177495 or FB:FBgn0004924 or MGI:98788 or PANTHER:PTN000033230 or PomBase:SPBC1703.14c or Top1 (Rattus norvegicus) or SGD:S000005366 or UniProtKB:P11387 or UniProtKB:P30181 or UniProtKB:Q581U8 or UniProtKB:Q5BGS7 or WB:WBGene000065951600115GO_CentralGO_REF:0000033

GO_REF:0000033
Top1enablesIEAEC:5.6.2.11600115UniProtGO_REF:0000003

GO_REF:0000003
Top1enablesIEAUniRule:UR0010797721600115UniProtGO_REF:0000104

GO_REF:0000104
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