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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621234
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdx2
Name: caudal type homeo box 2
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdx2increases response to substanceISOCdx2 (Mus musculus)6480464CTDCDX2 protein results in increased susceptibility to LipopolysaccharidesPMID:21131441
Cdx2multiple interactionsISOCDX2 (Homo sapiens)6480464CTD[Lipopolysaccharides co-treated with 6-formylindolo(3,2-b)carbazole] results in increased expression of CDX2 mRNA; [Lipopolysaccharides co-treated with Tetrachlorodibenzodioxin] results in increased expression of CDX2 mRNA; CDX2 protein affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]]PMID:27783115
Cdx2multiple interactionsISOCdx2 (Mus musculus)6480464CTDCDX2 protein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; CDX2 protein promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]PMID:21131441
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