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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621203
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rpl32
Name: ribosomal protein L32
Acc ID: CHEBI:84327
Term: torin 1
Definition: A member of the class of pyridoquinolines that is 9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2-one bearing an additional 4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl substituent at position 1. It is a potent inhibitor of mTOR and exhibits anti-cancer properties.
Chemical ID: MESH:C553294
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13470146480464CTD1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1, 6)naphthyridin-2(1H)-one results in decreased expression of RPL32 protein

PMID:25940091
multiple interactionsISORGD:13470146480464CTD1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1, 6)naphthyridin-2(1H)-one inhibits the reaction [EIF4G1 protein binds to RPL32 mRNA], 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1, 6)naphthyridin-2(1H)-one promotes the reaction [LARP1 protein binds to RPL32 mRNA], LARP1 protein promotes the reaction [1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1, 6)naphthyridin-2(1H)-one results in decreased expression of RPL32 protein]

PMID:25940091
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.