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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621176
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Scd
Name: stearoyl-CoA desaturase
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scddecreases expressionISOSCD (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of SCD mRNAPMID:20106945 PMID:21632981 PMID:22316170 PMID:26238291 PMID:32234424
Scddecreases expressionISOScd1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of SCD1 mRNAPMID:19770486
Scdincreases expressionISOScd1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of SCD1 mRNAPMID:22228805 PMID:32417428
Scdincreases methylationISOSCD (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of SCD promoterPMID:27901495
Scdmultiple interactionsISOSCD (Homo sapiens)6480464CTD[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of SCD mRNA; [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of SCD mRNAPMID:17690111
Scdmultiple interactionsISOScd1 (Mus musculus)6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SCD1 mRNAPMID:27858113
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