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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621168
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ogg1
Name: 8-oxoguanine DNA glycosylase
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ogg1decreases expressionEXP 6480464CTDEstradiol results in decreased expression of OGG1 mRNA; Estradiol results in decreased expression of OGG1 proteinPMID:24894866
Ogg1multiple interactionsEXP 6480464CTDresveratrol inhibits the reaction [Estradiol results in decreased expression of OGG1 mRNA]; resveratrol inhibits the reaction [Estradiol results in decreased expression of OGG1 protein]PMID:24894866
Ogg1affects expressionISOOGG1 (Homo sapiens)6480464CTDEstradiol affects the expression of OGG1 mRNAPMID:22082530
Ogg1multiple interactionsISOOGG1 (Homo sapiens)6480464CTD[Estradiol results in increased expression of OGG1 mRNA] which results in increased susceptibility to Cisplatin; [Estradiol results in increased expression of OGG1 mRNA] which results in increased susceptibility to Doxorubicin; decitabine affects the reaction [Estradiol affects the expression of OGG1 mRNA]PMID:22082530 PMID:28323900
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