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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621163
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mif
Name: macrophage migration inhibitory factor
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mifincreases expressionISOMif (Mus musculus)6480464CTD[Ozone results in increased expression of HIF1A] which results in increased expression of MIF; Ozone results in increased expression of MIF mRNAPMID:24040961 PMID:26752192
Mifincreases secretionISOMif (Mus musculus)6480464CTDOzone results in increased secretion of MIF proteinPMID:26752192
Mifmultiple interactionsISOMif (Mus musculus)6480464CTD3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazoleacetic acid methyl ester inhibits the reaction [Ozone results in increased expression of and results in increased secretion of MIF protein]; [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of MIF mRNA; Ozone results in increased expression of and results in increased secretion of MIF proteinPMID:26752192 PMID:34911549
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