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GENE - TERM ANNOTATION REPORT

RGD ID: 621159
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1rn
Name: interleukin 1 receptor antagonist
Acc ID: DOID:2841
Term: asthma
Definition: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. (DO)
Definition Source(s): http://www.nhlbi.nih.gov/health/dci/Diseases/Asthma/Asthma_WhatIs.html "DO" "DO", https://www.ncbi.nlm.nih.gov/books/NBK430901/ "DO" "DO", https://www.ncbi.nlm.nih.gov/books/NBK7223/ "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1rn ISOIL1RN (Homo sapiens)4142802RGD  
Il1rn ISOIL1RN (Homo sapiens)4143209RGD  
Il1rn ISOIL1RN (Homo sapiens)4143224RGDDNA, protein:repeat, decreased expression (human) 
Il1rnseverityISOIL1RN (Homo sapiens)4143225RGDprotein:increased expression:plasma 
Il1rnsusceptibilityISOIL1RN (Homo sapiens)4142864RGDDNA:polymorphism:intron (human) 
Il1rnsusceptibilityISOIL1RN (Homo sapiens)4143163RGDDNA:SNPs: :rs447713, rs3087271 (human) 
Il1rnsusceptibilityISOIL1RN (Homo sapiens)4143208RGDDNA:SNP: :rs2234678 (human) 
Il1rnsusceptibilityISOIL1RN (Homo sapiens)4143216RGDDNA:SNPs: :multiple (human) 
Il1rn ISOIL1RN (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:9176529
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