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GENE - TERM ANNOTATION REPORT

RGD ID: 621159
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1rn
Name: interleukin 1 receptor antagonist
Acc ID: DOID:0080474
Term: pustular psoriasis 14
Definition: A psoriasis characterized by sudden, repeated episodes of high-grade fever, generalized rash, and disseminated pustules, with hyperleukocytosis and elevated serum levels of C-reactive protein that has_material_basis_in homozygous or compound heterozygous mutation in the IL36RN gene on chromosome 2q14. (DO)
Definition Source(s): https://www.ncbi.nlm.nih.gov/pubmed/21848462 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1rn ISOIL1RN (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Generalized pustular psoriasisPMID:19494218 PMID:21792839 PMID:22940634 PMID:23698098 PMID:26100510 PMID:28492532
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