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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621159
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1rn
Name: interleukin 1 receptor antagonist
Acc ID: CHEBI:47381
Term: diclofenac
Definition: A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Chemical ID: MESH:D004008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1rndecreases expressionISOIl1rn (Mus musculus)6480464CTDDiclofenac results in decreased expression of IL1RN mRNAPMID:35537566
Il1rnincreases expressionISOIL1RN (Homo sapiens)6480464CTDDiclofenac results in increased expression of IL1RN mRNAPMID:9491209
Il1rnincreases expressionISOIl1rn (Mus musculus)6480464CTDDiclofenac results in increased expression of IL1RN mRNAPMID:26934552
Il1rnincreases secretionISOIL1RN (Homo sapiens)6480464CTDDiclofenac results in increased secretion of IL1RN proteinPMID:9491209
Il1rnmultiple interactionsISOIL1RN (Homo sapiens)6480464CTDLipopolysaccharides inhibits the reaction [Diclofenac results in increased secretion of IL1RN protein]PMID:9491209
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