Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621157
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Txn1
Name: thioredoxin 1
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Txn1affects expressionISOTXN (Homo sapiens)6480464CTDArsenic Trioxide affects the expression of TXN mRNAPMID:25873331
Txn1decreases expressionISOTxn1 (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of TXN proteinPMID:24157283
Txn1decreases response to substanceISOTXN (Homo sapiens)6480464CTDTXN protein results in decreased susceptibility to Arsenic TrioxidePMID:20707922 PMID:22590507
Txn1increases expressionISOTXN (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of TXN mRNAPMID:25258189
Txn1increases oxidationISOTXN (Homo sapiens)6480464CTDArsenic Trioxide results in increased oxidation of TXN protein; Arsenic Trioxide results in increased oxidation of TXN1 proteinPMID:17640917 PMID:18922898 PMID:26975474
Txn1increases response to substanceISOTXN (Homo sapiens)6480464CTDTXN1 results in increased susceptibility to Arsenic TrioxidePMID:18922898
Txn1multiple interactionsISOTxn1 (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of TXN protein]PMID:24157283
Go Back to source page   Continue to Ontology report