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GENE - TERM ANNOTATION REPORT

RGD ID: 621118
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nlgn2
Name: neuroligin 2
Acc ID: GO:0045202
Term: synapse
Definition: The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
Definition Source(s): GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nlgn2located_inISONlgn2 (Mus musculus)1624291RGD PMID:15681343

PMID:15681343
Nlgn2located_inISSUniProtKB:Q69ZK91600115BHF-UCLGO_REF:0000024

GO_REF:0000024
Nlgn2is_active_inIBAFB:FBgn0031866 or FB:FBgn0051146 or MGI:2179435 or MGI:2681835 or MGI:3775191 or PANTHER:PTN000168538 or Nlgn1 (Rattus norvegicus) or Nlgn2 (Rattus norvegicus) or Nlgn3 (Rattus norvegicus) or UniProtKB:Q8N0W4 or UniProtKB:Q9NZ94 or WB:WBGene000064121600115GO_CentralGO_REF:0000033

GO_REF:0000033
Nlgn2located_inIEAPANTHER:PTHR43903:SF31600115TreeGrafterGO_REF:0000118

GO_REF:0000118
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