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GENE - TERM ANNOTATION REPORT

RGD ID: 621114
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ttn
Name: titin
Acc ID: DOID:9007925
Term: Sudden Cardiac Death
Definition: Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)
Definition Source(s): MESH:D016757
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ttn ISOTTN (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Sudden cardiac arrest | ClinVar Annotator: match by term: Sudden cardiac deathPMID:19608031 PMID:24033266 PMID:25741868 PMID:26467025 PMID:28492532
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