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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621102
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Psmc4
Name: proteasome 26S subunit, ATPase 4
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDParaquat results in increased expression of PSMC4 mRNA

PMID:18198484
multiple interactionsISORGD:7315566480464CTD[Paraquat co-treated with Maneb] results in decreased expression of PSMC4 mRNA

PMID:26498265
multiple interactionsISORGD:7315576480464CTD[Maneb co-treated with Paraquat] results in decreased expression of PSMC4 mRNA, Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PSMC4 mRNA]

PMID:23963992
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.