GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Socs3 | affects expression | ISO | SOCS3 (Homo sapiens) | 6480464 | CTD | Arsenic affects the expression of SOCS3 mRNA | PMID:18414638 PMID:33736254 | Socs3 | decreases methylation | ISO | SOCS3 (Homo sapiens) | 6480464 | CTD | Arsenic results in decreased methylation of SOCS3 promoter | PMID:35490796 | Socs3 | increases expression | ISO | SOCS3 (Homo sapiens) | 6480464 | CTD | Arsenic results in increased expression of SOCS3 mRNA | PMID:18039032 | Socs3 | multiple interactions | ISO | SOCS3 (Homo sapiens) | 6480464 | CTD | [Folic Acid co-treated with Arsenic] affects the expression of SOCS3 mRNA; [Palmitic Acid co-treated with Arsenic] affects the expression of SOCS3 mRNA; [S-Adenosylmethionine co-treated with Arsenic] affects the expression of SOCS3 mRNA; [S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of SOCS3 promoter]] which results in decreased expression of SOCS3 mRNA; [sodium arsenite results in increased abundance of Arsenic] promotes the reaction [Benzo(a)pyrene results in decreased expression of SOCS3 mRNA]; [sodium arsenite results in increased abundance of Arsenic] promotes the reaction [Benzo(a)pyrene results in decreased expression of SOCS3 protein]; Folic Acid inhibits the reaction [Arsenic results in decreased methylation of SOCS3 promoter]; S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of SOCS3 promoter]; SOCS3 protein inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]]; SOCS3 protein inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]]; SOCS3 protein inhibits the reaction [Benzo(a)pyrene promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of AKT1 protein]]; SOCS3 protein inhibits the reaction [Benzo(a)pyrene promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK1 protein]]; SOCS3 protein inhibits the reaction [Benzo(a)pyrene promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK3 protein]]; SUV39H1 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] promotes the reaction [Benzo(a)pyrene results in decreased expression of SOCS3 protein]] | PMID:32062438 PMID:33736254 PMID:35490796 | | ||||||||||||||||||||||
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