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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621083
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd2
Name: cyclin D2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd2affects expressionEXP 6480464CTDbisphenol A affects the expression of CCND2 mRNAPMID:25181051
Ccnd2increases expressionEXP 6480464CTDbisphenol A results in increased expression of CCND2 mRNAPMID:32145629
Ccnd2decreases activityISOCcnd2 (Mus musculus)6480464CTDbisphenol A results in decreased activity of CCND2 proteinPMID:33485121
Ccnd2decreases expressionISOCCND2 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of CCND2; bisphenol A results in decreased expression of CCND2 mRNAPMID:26363213 PMID:28729173 PMID:30036487
Ccnd2decreases expressionISOCcnd2 (Mus musculus)6480464CTDbisphenol A results in decreased expression of CCND2 mRNAPMID:33485121
Ccnd2decreases methylationISOCCND2 (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of CCND2 genePMID:31601247
Ccnd2increases expressionISOCCND2 (Homo sapiens)6480464CTDbisphenol A results in increased expression of CCND2 mRNA; bisphenol A results in increased expression of CCND2 proteinPMID:29307715 PMID:33670352
Ccnd2multiple interactionsISOCCND2 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CCND2 mRNAPMID:28628672
Ccnd2multiple interactionsISOCcnd2 (Mus musculus)6480464CTD4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [bisphenol A results in decreased activity of CCND2 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in decreased activity of CCND2 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [bisphenol A results in decreased activity of CCND2 protein]PMID:33485121
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