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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgm2
Name: transglutaminase 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgm2decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of TGM2 mRNAPMID:21215274 PMID:33387578 PMID:34747641
Tgm2affects expressionISOTgm2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of TGM2 mRNAPMID:19770486 PMID:21570461
Tgm2decreases expressionISOTGM2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of TGM2 mRNAPMID:19619570
Tgm2decreases expressionISOTgm2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of TGM2 mRNAPMID:15652763
Tgm2increases expressionISOTGM2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of TGM2 mRNAPMID:16480812
Tgm2increases expressionISOTgm2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of TGM2 mRNAPMID:27562557
Tgm2multiple interactionsISOTGM2 (Homo sapiens)6480464CTD7-ketocholesterol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TGM2 mRNA]; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TGM2 mRNA; Butyrates inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Tretinoin results in increased expression of TGM2 mRNA]]; Tetrachlorodibenzodioxin inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of TGM2 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Tretinoin results in increased expression of TGM2 mRNA]PMID:10910994 PMID:12075115 PMID:16480812 PMID:19619570
Tgm2multiple interactionsISOTgm2 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TGM2 mRNAPMID:17942748
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