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GENE - TERM ANNOTATION REPORT

RGD ID: 621080
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nudt1
Name: nudix hydrolase 1
Acc ID: GO:0035539
Term: 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
Definition: Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.
Definition Source(s): PMID:17804481, PMID:7782328, PMID:7859359, RHEA:31575
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nudt1enablesISONUDT1 (Homo sapiens)1624291RGD PMID:10608900 PMID:11139615 PMID:22556419

PMID:10608900 PMID:11139615 PMID:22556419
Nudt1enablesISSUniProtKB:P366391600115UniProtGO_REF:0000024

GO_REF:0000024
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