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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621065
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Csf2
Name: colony stimulating factor 2
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Csf2decreases expressionISOCSF2 (Homo sapiens)6480464CTDDexamethasone results in decreased expression of CSF2 mRNAPMID:10596698
Csf2increases activityISOCSF2 (Homo sapiens)6480464CTDDexamethasone results in increased activity of CSF2 proteinPMID:11730731
Csf2multiple interactionsISOCSF2 (Homo sapiens)6480464CTD[Theophylline co-treated with Dexamethasone] inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; [trichostatin A co-treated with Dexamethasone] inhibits the reaction [IL1B protein promotes the reaction [H4C16 protein modified form binds to CSF2 promoter]]; Dexamethasone inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; Dexamethasone inhibits the reaction [IL13 protein results in increased secretion of CSF2 protein]; Dexamethasone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; Dexamethasone inhibits the reaction [IL4 protein results in increased secretion of CSF2 protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CSF2 protein]; Dexamethasone inhibits the reaction [lipoteichoic acid results in increased secretion of CSF2 protein]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of CSF2 mRNA]; Dexamethasone inhibits the reaction [TNF protein results in increased secretion of CSF2 protein]; Dexamethasone promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 mRNA]]; trichostatin A inhibits the reaction [[Theophylline co-treated with Dexamethasone] inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]]; trichostatin A inhibits the reaction [Dexamethasone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]]PMID:12070353 PMID:12077271 PMID:14998300 PMID:16908450 PMID:19255438 PMID:20801891 PMID:23981542 PMID:27568862
Csf2multiple interactionsISOCsf2 (Mus musculus)6480464CTDDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CSF2 mRNA]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CSF2 protein]PMID:16880258 PMID:27568862
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