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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621059
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccna2
Name: cyclin A2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccna2increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of CCNA2 proteinPMID:17141280
Ccna2multiple interactionsEXP 6480464CTDAHR affects the reaction [Benzo(a)pyrene results in increased activity of [CCNA2 protein binds to CDK2 protein]]; AHR affects the reaction [Benzo(a)pyrene results in increased expression of CCNA2 protein]; Benzo(a)pyrene results in increased activity of [CCNA2 protein binds to CDK2 protein]PMID:17141280
Ccna2decreases expressionISOCCNA2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of CCNA2 mRNA; Benzo(a)pyrene results in decreased expression of CCNA2 proteinPMID:16120219 PMID:16269432 PMID:20064835 PMID:21802500
Ccna2decreases expressionISOCcna2 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of CCNA2 mRNAPMID:17942131 PMID:19770486 PMID:21569818
Ccna2increases expressionISOCCNA2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of CCNA2 mRNAPMID:33411230
Ccna2increases expressionISOCcna2 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CCNA2 mRNAPMID:32417428 PMID:35678645
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