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GENE - TERM ANNOTATION REPORT

RGD ID: 621047
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Plrg1
Name: pleiotropic regulator 1
Acc ID: GO:0000974
Term: Prp19 complex
Definition: A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p.
Definition Source(s): GOC:krc, PMID:16540691, PMID:19239890
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Plrg1located_inISOPLRG1 (Homo sapiens)1624291RGD PMID:20176811

PMID:20176811
Plrg1part_ofIEAUniProtKB:O43660 or ensembl:ENSP000004244171600115EnsemblGO_REF:0000107

GO_REF:0000107
Plrg1part_ofIBAFB:FBgn0030365 or PANTHER:PTN000460428 or PomBase:SPBP22H7.07 or SGD:S000006072 or UniProtKB:O436601600115GO_CentralGO_REF:0000033

GO_REF:0000033
Plrg1part_ofIEAPANTHER:PTHR19923:SF01600115TreeGrafterGO_REF:0000118

GO_REF:0000118
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