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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1decreases activityISODNMT1 (Homo sapiens)6480464CTDepigallocatechin gallate results in decreased activity of DNMT1 proteinPMID:16037419
Dnmt1increases expressionISODNMT1 (Homo sapiens)6480464CTDepigallocatechin gallate results in increased expression of DNMT1 mRNAPMID:25839702
Dnmt1multiple interactionsISODNMT1 (Homo sapiens)6480464CTDepigallocatechin gallate binds to and results in decreased activity of DNMT1 protein; Magnesium promotes the reaction [epigallocatechin gallate results in decreased activity of DNMT1 protein]PMID:14633667 PMID:16037419
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